Hola Brian,
Initially I would look to something else...
Have you been increasing or adjusting the bubble rate lately?
I have seen that changes in the bubble rate can cause fish stress for me even several days to a week later. It is a cumulative effect.
I don't rule it out, but have you made ANY OTHER changes? If so, I would look to them.
I have changed my EI dosing considerably over a week or two and not changed the c02 and had no issues.
Lo siento, pero yo olvide si tienes DIY c02 o no? Is that right? (I am sorry, but do you have DIY c02 or not?) was my question...
Hope this helps.